Bioactive Small Molecules
Medchemexpress LLC PI3K/mTOR Inhibitor-13 (sodium) | 2361009-23-4 | C20H13F2N5NaO3S | 50 MG
PI3K/mTOR Inhibitor-13 (sodium) is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. It shows potential applications in sexual diseases, solid tumor, and idiopathic pulmonary fibrosis (IPF). Intended for research use only, this white to off-white solid has a purity of 98.11% and a molecular weight of 464.40.
- Inhibits HFL1 cell proliferation in a dose-dependent manner.
- Increases α-SMA/Tubulin expression in HFL1 cells.
- Evaluated for pharmacokinetic parameters in rats, mice, dogs, and monkeys.
Medchemexpress LLC N-(4-(2-phenyl-4-(p-tolyl)piperazine-1-carbonyl)phenyl)acetamide | 1629166-02-4 | 99.6% | 413.51 g/mol | C26H27N3O2 | 100 MG
SBC-110736 is a small-molecule inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) supplied as a white to off-white solid for research use. It has formula C26H27N3O2 and a molecular weight of 413.51 g/mol and is used in preclinical studies targeting PCSK9-related pathways.
- High purity (≈99.6%).
- White to off-white solid suitable for handling and formulation.
- Molecular weight 413.51 g/mol and formula C26H27N3O2.
- Soluble in DMSO for stock solution preparation.
- Suitable for preclinical biochemical and in vivo studies of PCSK9 modulation.
- Available in multiple pack sizes, including 100 MG.
Medchemexpress LLC KJ Pyr 9 | 581073-80-5 | 99.6% | 385.37 | 1 ML
KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. It interferes with MYC-MAX complex formation and specifically inhibits MYC-induced oncogenic transformation in cell culture. It preferentially interferes with the proliferation of MYC-overexpressing human and avian cells and reduces the MYC-driven transcriptional signature.
- Inhibits MYC-MAX complex formation
- Inhibits MYC-induced oncogenic transformation
- Preferentially interferes with MYC-overexpressing cell proliferation
- Reduces MYC-driven transcriptional signature
- Can halt tumor growth in vivo
Cayman Chemical ANTIBODY GDC-6036 10mg
A covalent inhibitor of K-RasG12C; decreases tumor volume in a PaCa-2 pancreatic cancer mouse xenograft model at 1 to 100 mg/kg per day
Cayman Chemical 4-methoxy PCEhydrochlorIde 5mg
An analytical reference standard categorized as an arylcyclohexylamine; intended for research and forensic applications
Cayman Chemical ANTIBODY 8 S-HETrE 250ug
A metabolite of GLA; serum levels are decreased in a mouse model of high-fat high-sucrose diet-induced obesity
Medchemexpress LLC LPA5 antagonist 1 | 2839471-45-1 | C28H26N2O4S | 5 MG
LPA5 antagonist 1 is a potent and selective lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 of 32 nM. It demonstrates high blood-brain-barrier permeability and anti-nociceptive activity. This compound is useful in inflammatory and neuropathic pain research.
- Potent and selective LPA5 antagonist (IC50=32 nM)
- Exhibits high blood-brain-barrier permeability
- Demonstrates anti-nociceptive activity
- Useful in inflammatory and neuropathic pain research
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Cayman Chemical SB-243213hydrochlorIde 5mg
A 5-HT2C receptor inverse agonist; selective for 5-HT2C over the 5-HT2A and 5-HT2B receptors (Kis = 0.001, 0.158, and 0.1 µM, respectively) and CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 (IC50s = >100, 23, >100, >100, and >100 µM, respectively); reduces the basal activity of 5-HT2C in HEK293 cells expressing the human receptor (pKB = 9.5); reverses mCPP-induced hypolocomotion in rats (ID50 = 0.7 mg/kg); has anxiolytic-like activity in the social interaction test in rats at 0.2-5 mg/kg
Cayman Chemical Rhodojaponin III 5MG
A diterpenoid with insecticidal and antinociceptive activities; reduces pupation and the number of Colorado potato beetle (L. decemlineata) larvae on, and damage to, potato plants at 75 and 150 ppm; has antinociceptive effects in mouse models of chemical, inflammatory, and neuropathic pain, including the acetic acid writhing test (ID50 = 0.0469 mg/kg); increases the paw withdrawal threshold for mechanical stimuli in a mouse model of diabetic peripheral neuropathic pain at 0.04 and 0.08 mg/kg; toxic to mice (LD50 = 0.271 mg/kg)
Cayman Chemical 5 6epoxy13cIs RetInoIc AcI 1mg
A metabolite of 13-cis retinoic acid; formed when 13-cis retinoic acid undergoes cooxidation by PGH synthase in the presence of hydroperoxides or peroxyl radicals; a potential impurity found in commercial preparations of 13-cis retinoic acid
Cayman Chemical LDN-192960hydrochlorIde 5mg
An inhibitor of haspin and DYRK2 (IC50s = 10 and 48 nM, respectively); selective for haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM)
Cayman Chemical ANTIBODY Calhex 231 5mg
A negative allosteric modulator of CaSR that blocks calcium-mediated activation (IC50 = 0.39 µM); attenuates the activation of CaSR by calcimimetics
Medchemexpress LLC GNE-477 | 1032754-81-6 | 98.8% | 504.63 | 10 MG
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
- Potent and efficacious dual PI3K/mTOR inhibitor
- Available as a solid or a solution in DMSO
- Powder can be stored at -20°C for 3 years or 4°C for 2 years
- Solution in solvent can be stored at -80°C for 2 years or -20°C for 1 year
- Soluble in DMSO at 16.67 mg/mL (33.03 mM), requiring ultrasonic treatment
Medchemexpress LLC L-Phenylalanine, 3-(methylsulfonyl)- | 1270093-99-6 | ≥97.0% | 243.28 | 100 MG
Lifitegrast impurity 6 is an impurity of Lifitegrast. This chemical is intended for laboratory use as a drug intermediate and for the manufacture of other substances. It is provided as a white to off-white solid.
- Molecular formula: C10H13NO4S
- Molecular weight: 243.28
- Purity: ≥97.0%
- Appearance: White to off-white solid
- Target: Drug intermediate
- Identified uses: Laboratory chemicals, manufacture of substances
- Storage at room temperature: 3 years
- Storage in solvent at -80°C: 2 years
- Storage in solvent at -20°C: 1 year
- Stable under recommended storage conditions
- For research use only, not fully validated for medical applications